Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HLA and sarcoidosis.

N K Mehra1, S Bovornkitti

  • 1Department of Anatomy, All India Institute of Medical Sciences, New Delhi.

Sarcoidosis
|September 1, 1988
PubMed
Summary
This summary is machine-generated.

Human Leukocyte Antigen (HLA) types, specifically HLA-B8 and HLA-DR3, are linked to acute sarcoidosis. However, these HLA alleles are not associated with the underlying genes that cause sarcoidosis susceptibility.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of fetal liver condition media derived cytokines(IL-6 and Flt-3) on human bone marrow stem cells colony formation.

Cytokine·2022
Same author

In vitro expansion of fetal liver hematopoietic stem cells.

Scientific reports·2021
Same author

IMPORTANCE OF DONOR SELECTION IN RENAL TRANSPLANTATION.

Medical journal, Armed Forces India·2017
Same author

SENSITIZATION STATE OF POTENTIAL LIVE RELATED DONOR RENAL TRANSPLANT PATIENTS.

Medical journal, Armed Forces India·2017
Same author

CLINICAL APPLICATION OF FLOW CYTOMETRY IN LIVE RELATED DONOR RENAL TRANSPLANTATION.

Medical journal, Armed Forces India·2017
Same author

IMMUNOLOGICAL MONITORING IN TRANSPLANTATION.

Medical journal, Armed Forces India·2017
Same journal

Non-sarcoid granulomatous disease with involvement of the lungs.

Sarcoidosis·1995
Same journal

Granuloma formation signifies a Th1 cell profile.

Sarcoidosis·1995
Same journal

Japan Society of Sarcoidosis 14th annual meeting. Hiroshima, October 20-21, 1994. Abstracts.

Sarcoidosis·1995
Same journal

Increase of serum copper concentration in Löfgren syndrome.

Sarcoidosis·1995
Same journal

Mucormycosis in a patient with sarcoidosis.

Sarcoidosis·1995
Same journal

Sarcoidosis following beta-interferon therapy for multiple myeloma.

Sarcoidosis·1995
See all related articles

Area of Science:

  • Immunogenetics
  • Rheumatology

Background:

  • Sarcoidosis is an inflammatory disease with a complex etiology.
  • Human Leukocyte Antigen (HLA) genes are known to influence immune responses and disease susceptibility.

Purpose of the Study:

  • To review current data on the association between HLA alleles and sarcoidosis.
  • To investigate the relationship between specific HLA types and the acute form of sarcoidosis.

Main Methods:

  • Review of existing epidemiological and genetic studies on HLA and sarcoidosis.
  • Analysis of data regarding the prevalence of specific HLA alleles in sarcoidosis patients.

Main Results:

  • A significant association exists between HLA-B8 and HLA-DR3 alleles and the acute presentation of sarcoidosis.

Related Experiment Videos

  • No genetic linkage was found between the identified HLA-associated alleles and the primary susceptibility genes for sarcoidosis.

    • Conclusions:

    • Specific HLA alleles, namely HLA-B8 and HLA-DR3, are associated with acute sarcoidosis.
    • The genetic basis of sarcoidosis susceptibility is not directly explained by the identified HLA associations.