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Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases
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Targeting Plasmepsins-An Achilles' Heel of the Malaria Parasite
Jeremy N Burrows1, Dominique Soldati-Favre2
1Medicines for Malaria Venture, Meyrin 1215, Switzerland.
Cell Host & Microbe
|April 10, 2020
Abstract:
Recently, two Plasmodium aspartyl proteases were identified as druggable targets impacting parasite survival. In this issue of Cell Host & Microbe, Favuzza et al. describe the optimization of a compound series acting on both targets, heralding the prospect of a new class of antimalarials for clinical studies.
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