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Related Experiment Video

Updated: Dec 24, 2025

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments

Published on: November 9, 2017

GFAP IgG associated inflammatory polyneuropathy.

Pritikanta Paul¹, Andrew McKeon², Sean J Pittock²

¹Department of Neurology, Mayo Clinic, Rochester, MN, United States of America.

Journal of Neuroimmunology

|April 10, 2020

Summary

This summary is machine-generated.

Glial fibrillary acidic protein (GFAP)-IgG associated neuropathy is a rare but treatable immune-mediated condition. Early diagnosis and immunotherapy can lead to favorable outcomes in patients with GFAP neuropathy.

Keywords:

Antibodies GFAP Peripheral neuropathy Polyradiculoneuropathy

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Last Updated: Dec 24, 2025

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments

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Published on: November 9, 2017

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Published on: February 8, 2019

Experimental Approaches for Biochemical Analysis of Glial Fibrillary Acidic Protein and Its Disease-associated Variants

Experimental Approaches for Biochemical Analysis of Glial Fibrillary Acidic Protein and Its Disease-associated Variants

Published on: November 28, 2025

Area of Science:

Neuroimmunology
Neuropathology

Background:

Glial fibrillary acidic protein (GFAP)-IgG is typically linked to meningoencephalomyelitis.
Peripheral neuropathy is an uncommon manifestation of GFAP-IgG.

Observation:

Reviewed six cases of GFAP-IgG associated peripheral neuropathy.
Five patients presented initially with neuropathy, often acute/subacute polyradiculoneuropathy or proximal nerve involvement.
Electrophysiological studies indicated demyelinating neuropathies in three patients.

Findings:

Nerve biopsies revealed T-cell predominant perivascular inflammatory infiltrates.
All patients who received immunotherapy showed a positive clinical response.

Implications:

GFAP-IgG neuropathy is a distinct, treatable immune-mediated peripheral neuropathy.
It can manifest independently of or concurrently with meningoencephalomyelitis.
Highlights the importance of considering GFAP-IgG in the differential diagnosis of immune-mediated neuropathies.