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Related Concept Videos

Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

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Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia01:30

Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia

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Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Routes of Drug Administration: Overview01:22

Routes of Drug Administration: Overview

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Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
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Local Anesthetics: Chemistry and Structure-Activity Relationship01:30

Local Anesthetics: Chemistry and Structure-Activity Relationship

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Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...
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Related Experiment Video

Updated: Dec 24, 2025

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
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Developing a Topical Adjunct to Injectable Procedures.

Alan D Widgerow, Carolyn Jacob, Melanie D Palm

    Journal of Drugs in Dermatology : JDD
    |April 10, 2020
    PubMed
    Summary

    A new post-injection serum significantly reduces bruising after aesthetic procedures. This topical product, utilizing peptides and active agents, demonstrated an 81% improvement in bruise resolution compared to a moisturizer.

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    Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
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    Area of Science:

    • Aesthetic Medicine
    • Dermatology
    • Biotechnology

    Background:

    • Injectable procedures are the most common aesthetic treatments.
    • These procedures can lead to side effects like bruising, swelling, and infection.
    • There is a need for adjunct products to manage side effects and enhance results.

    Purpose of the Study:

    • To outline the scientific validation of a novel post-injection serum.
    • To evaluate the product's efficacy in managing bruising, swelling, and pain.
    • To assess the product's adjunctive benefits for volumetric enhancement and skin regeneration.

    Main Methods:

    • Development of a serum with peptides and active agents targeting iron reduction and macrophage absorption.
    • Inclusion of agents to stimulate collagen, elastin, and hyaluronic acid.
    • In vivo testing to evaluate bruise resolution compared to a bland moisturizer.

    Main Results:

    • The study product demonstrated a 73% reduction in bruise color intensity at days 2/3.
    • 81% of subjects showed improved bruising compared to the control group.
    • The serum contains anti-inflammatory, antimicrobial, and antibiofilm properties.

    Conclusions:

    • The developed serum is an effective adjunct to injectable therapies.
    • It successfully manages common side effects like bruising.
    • The product also offers potential benefits for skin regeneration and safety.