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Diabetes Mellitus Itself Increases Cardio-Cerebrovascular Risk and Renal Complications in Primary Aldosteronism

Aya Saiki1, Michio Otsuki1, Daisuke Tamada1

  • 1Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.

The Journal of Clinical Endocrinology and Metabolism
|April 11, 2020
PubMed

Insights

Diabetes Mellitus (DM) increases cardiovascular and renal risks in Primary Aldosteronism (PA) patients. Managing DM is crucial for better outcomes in this population.

Area of Science:

  • Endocrinology
  • Nephrology
  • Cardiology

Background:

  • Primary aldosteronism (PA) patients have a higher prevalence of diabetes mellitus (DM) compared to essential hypertension and general populations.
  • DM is a significant risk factor for cardio-cerebrovascular (CCV) diseases and renal complications, but its specific impact in PA remains unclear.

Purpose of the Study:

  • To investigate the influence of coexistent DM on the risk of CCV events.
  • To assess the effect of DM on the progression of renal complications in PA patients.

Main Methods:

  • A multi-institutional, cross-sectional study enrolled 2524 PA patients from the Japan PA registry (2006-2016).
  • Patients were categorized into DM and non-DM groups.
  • Logistic and linear regression analyses compared CCV events and renal complications between the groups.

Main Results:

  • DM significantly elevated the odds of CCV events (OR 1.59) and proteinuria (OR 2.25).
  • DM showed a significant correlation with declining estimated glomerular filtration rate (β = .05, P = .02).

Conclusions:

  • This study identifies DM as an independent risk factor for CCV events and renal complications in PA patients.
  • Integrated management of DM alongside PA treatment is recommended for improved patient outcomes.
Abstract

Keywords:
cardio-cerebrovascular eventsdiabetes mellituseGFRprimary aldosteronismproteinuria

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