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Relationship between Sphk1/S1P and microRNAs in human cancers

Saeideh Gholamzadeh Khoei1,2, Hamid Sadeghi3, Pouria Samadi1,2

  • 1Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Biotechnology and Applied Biochemistry
|April 11, 2020
PubMed

Insights

Sphingosine kinase 1 (SphK1) and microRNAs are key players in cancer. Their complex interactions influence cancer progression and offer potential for novel therapeutic strategies in malignancies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Sphingosine kinase 1 (SphK1) phosphorylates sphingosine to sphingosine 1-phosphate (S1P), a critical signaling lipid.
  • Aberrant SphK1/S1P signaling is linked to poor prognosis and promotes cancer hallmarks like proliferation, angiogenesis, and metastasis.
  • MicroRNAs (miRNAs) are small noncoding RNAs regulating gene expression post-transcriptionally, impacting cancer initiation and progression.

Purpose of the Study:

  • To review the intricate relationship between SphK1 and miRNA functions in human malignancies.
  • To elucidate the reciprocal regulatory mechanisms between SphK1 and miRNAs in cancer.
  • To explore the potential of targeting the SphK1-miRNA axis for novel cancer treatment strategies.

Main Methods:

  • Literature review synthesizing current research on SphK1 and miRNA interactions in cancer.
  • Analysis of studies detailing miRNA regulation of SphK1 expression and vice versa.
  • Discussion of the implications of these interactions for cancer biology and therapeutic development.

Main Results:

  • SphK1 activity influences the expression and function of various cancer-associated miRNAs.
  • Conversely, specific miRNAs can modulate SphK1 expression levels and activity.
  • This bidirectional regulation plays a significant role in cancer initiation, progression, and metastasis.

Conclusions:

  • The interplay between SphK1 and miRNAs represents a crucial regulatory network in human cancers.
  • Understanding these interactions is vital for deciphering cancer pathogenesis.
  • Targeting the SphK1-miRNA axis holds promise for developing innovative therapeutic approaches against malignancies.
Keywords:
cancerinteractionmicroRNAssphingosine 1-phosphatesphingosine kinase type 1

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