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Updated: Dec 24, 2025

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
Published on: November 27, 2016
A Photoswitchable Inhibitor of the Human Serotonin Transporter
Bichu Cheng1,2, Johannes Morstein2, Lucy Kate Ladefoged3
1School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.
Abstract:
The human serotonin transporter (hSERT) terminates serotonergic signaling through reuptake of neurotransmitter into presynaptic neurons and is a target for many antidepressant drugs. We describe here the development of a photoswitchable hSERT inhibitor, termed azo-escitalopram, that can be reversibly switched between trans and cis configurations using light of different wavelengths. The dark-adapted trans isomer was found to be significantly less active than the cis isomer, formed upon irradiation.
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