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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

652
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
652
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

669
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
669

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Related Experiment Video

Updated: Dec 24, 2025

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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Stimuli-responsive nano-assemblies for remotely controlled drug delivery.

Fangyuan Li1, Yu Qin2, Jiyoung Lee3

  • 1Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|April 11, 2020
PubMed
Summary

Stimuli-responsive nano-assemblies offer precise drug delivery. This review covers advancements in remotely controlled drug delivery systems (DDSs) for intelligent nanomedicine development.

Keywords:
Bio-cleanable nano-systemsControlled drug deliveryNano-assembliesStimuli-responsiveness

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Area of Science:

  • Nanotechnology and Materials Science
  • Biomedical Engineering
  • Drug Delivery Systems

Background:

  • Stimuli-responsive nano-assemblies enable controlled drug release via structural transitions triggered by external or internal stimuli.
  • Remotely controlled drug delivery systems (DDSs) utilizing exogenous stimuli (light, magnetic fields, temperature) offer high accuracy and reliability.

Purpose of the Study:

  • To review current state-of-the-art nano-assembly synthesis technologies.
  • To summarize recent advances in remotely controlled DDSs based on nano-assemblies activated by various stimuli.
  • To highlight progress in bio-cleanable stimuli-responsive nano-assemblies for clinical translation.

Main Methods:

  • Review of existing literature on stimuli-responsive nano-assemblies and their applications in drug delivery.
  • Analysis of nano-assembly synthesis techniques and their responsiveness to different stimuli.
  • Discussion of clinical translation potential, focusing on bio-cleanable materials.

Main Results:

  • Overview of nano-assembly synthesis strategies for stimuli-responsive drug delivery.
  • Summary of remotely controlled DDSs leveraging exogenous stimuli (light, magnetic, thermal) and dual-stimuli.
  • Exploration of bio-cleanable nano-assemblies for improved safety and clinical applicability.

Conclusions:

  • Stimuli-responsive nano-assemblies represent a significant advancement in developing intelligent nanomedicines.
  • Remotely controlled DDSs offer enhanced spatial and temporal drug release capabilities.
  • Further research into bio-cleanable materials is crucial for successful clinical translation.