Related Experiment Video
Updated: Dec 24, 2025

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
Human Serum Albumin Labelled with Sterically-Hindered Nitroxides as Potential MRI Contrast Agents
Sergey Dobrynin1, Sergei Kutseikin2, Denis Morozov1
1N.N. Vorozhtsov Institute of Organic Chemistry, SB RAS 630090 Novosibirsk, Russia.
Abstract:
Four albumin-nitroxide conjugates were prepared and tested as metal-free organic radical contrast agents (ORCAs) for magnetic resonance imaging (MRI). Each human serum albumin (HSA) carrier bears multiple nitroxides conjugated via homocysteine thiolactones. These molecular conjugates retain important physical and biological properties of their HSA component, and the resistance of their nitroxide groups to bioreduction was retained or enhanced. The relaxivities are similar for these four conjugates and are much greater than those of their individual components: the HSA or the small nitroxide molecules. This new family of conjugates has excellent prospects for optimization as ORCAs.
More Related Videos
Related Concept Videos
Magnetic Resonance Imaging
Imaging Studies I: CT and MRI
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Imaging Studies for Cardiovascular System IV: CMRI
Imaging Studies IV: Magnetic Resonance Imaging
Radiological Investigation I: X-ray and CT

