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Pathogenomics insights for understanding Pasteurella multocida adaptation.

Raquel Hurtado1, Lenin Maturrano2, Vasco Azevedo3

  • 1Laboratory of Cellular and Molecular Genetics, Federal University of Minas Gerais, Belo Horizonte, 31270-901, Minas Gerais, Brazil; Laboratory of Molecular Biology and Genetics, Veterinary Medicine Faculty, San Marcos University, Lima, Peru.

International Journal of Medical Microbiology : IJMM
|April 12, 2020
PubMed
Summary
This summary is machine-generated.

Genomic analysis reveals Pasteurella multocida

Keywords:
AdaptationEvolutionGenomicsMobile genetic elementsVirulence

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Area of Science:

  • Veterinary microbiology
  • Genomics
  • Evolutionary biology

Background:

  • Pasteurella multocida is a versatile veterinary pathogen causing diverse diseases in animals.
  • Its genomic flexibility, host adaptation, and pathogenesis present complex challenges.
  • Understanding intraspecies diversity is crucial for disease control.

Purpose of the Study:

  • To review the genomic relationships and evolutionary dynamics of Pasteurella multocida.
  • To elucidate how genomic features influence host adaptation and pathogenesis.
  • To highlight the role of comparative genomics in understanding strain diversity.

Main Methods:

  • Multilocus sequence typing, serotyping, and genotyping.
  • Analysis of virulence genes and single nucleotide polymorphisms (SNPs).
  • Comparative genomic and pan-genomic approaches.
  • Identification of mobile genetic elements (MGEs).
  • Diversification selection analysis.

Main Results:

  • Genomic flexibility allows for significant variation in gene content and adaptation.
  • Mobile genetic elements (MGEs) show lineage-specific patterns, suggesting evolutionary convergence.
  • Surface proteins are under selection pressure, contributing to interstrain heterogeneity and adaptability.
  • A high number of sequenced genomes aids accurate genomic and epidemiological interpretation.

Conclusions:

  • Genomic insights are key to understanding Pasteurella multocida diversity and evolution.
  • The flexible genome and MGEs play significant roles in host adaptation and disease.
  • This review provides a comprehensive genomic perspective on this important veterinary pathogen.