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Friedel-Crafts Type Methylation with Dimethylhalonium Salts

Sebastian Hämmerling1, Patrick Voßnacker1, Simon Steinhauer1

  • 1Institut für Chemie und Biochemie, Freie Universität Berlin, Fabeckstr.34/36, 14195, Berlin, Germany.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|April 12, 2020
PubMed
Summary

The dimethylchloronium salt effectively methylates electron-deficient aromatic systems in Friedel-Crafts reactions. Quantum-chemical calculations explored the cation

Keywords:
electrophilic substitutionhalonium ionsmethylationreaction mechanismweakly coordinating anion

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