Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

3.9K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.9K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

3.0K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.0K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.1K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.1K
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.3K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.3K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

1.6K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.6K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

3.2K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Severe asthma and remission prospects in Europe (SHARP): insights from a multicentre observational study based on the European Severe Asthma Registry.

The Lancet. Respiratory medicine·2026
Same author

[Lung cancer and the environment : state of the art and perspectives].

Revue medicale de Liege·2026
Same author

[Impact of air pollution on the respiratory system from a One Health perspective].

Revue medicale de Liege·2026
Same author

[Environmental exposome and interstitial lung diseases].

Revue medicale de Liege·2026
Same author

Rapid & sustained benefit of benralizumab in severe eosinophilic asthma: the BE-REAL study.

Respiratory medicine·2026
Same author

Clinical Remission in Severe T2-High Asthma in Real Life After Anti-IgE, Anti-IL-5 and Anti-IL5R: A Potential Role for CRP as a Biomarker.

Clinical and translational allergy·2026
Same journal

Notch signaling in anti-VEGF resistant arteriolar choroidal neovascularization.

Biochemical pharmacology·2026
Same journal

Methylated SNHG3 lncRNA counteracts PSMD4-inhibited angiogenesis by HnRNPA2B1 SUMOylation in peripheral arterial disease.

Biochemical pharmacology·2026
Same journal

The organelle-targeting duality of nanomaterials: physicochemical property-guided therapeutic effects and toxicological outcomes.

Biochemical pharmacology·2026
Same journal

The central role of endoplasmic reticulum stress in Parkinson's disease and targeted therapeutic strategies.

Biochemical pharmacology·2026
Same journal

Mechanisms involved in the regulation of carbohydrate and lipid metabolism by oleanane-type pentacyclic triterpenes.

Biochemical pharmacology·2026
Same journal

Myricitrin alleviates paraquat-induced acute lung injury via PERK pathway to attenuate endoplasmic reticulum stress and mitochondrial dysfunction.

Biochemical pharmacology·2026
See all related articles

Related Experiment Video

Updated: Dec 24, 2025

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

1.2K

Eosinophil diversity in asthma.

Glenn Van Hulst1, Hashini M Batugedara2, Joseph Jorssen1

  • 1Laboratory of Cellular and Molecular Immunology, GIGA Institute, Liège University, Liège, Belgium; Faculty of Medicine, Liège University, Liège, Belgium.

Biochemical Pharmacology
|April 12, 2020
PubMed
Summary
This summary is machine-generated.

Eosinophils, immune cells linked to asthma, may have diverse roles beyond harm. Understanding eosinophil subsets could lead to personalized treatments for severe eosinophilic asthma.

Keywords:
AsthmaEosinophilImmune cell subsetsImmunotherapyInterleukin-5

More Related Videos

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

6.4K
Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

28.4K

Related Experiment Videos

Last Updated: Dec 24, 2025

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

1.2K
Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

6.4K
Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

28.4K

Area of Science:

  • Immunology
  • Respiratory Medicine
  • Cell Biology

Background:

  • Eosinophils are innate immune cells implicated in eosinophilic asthma.
  • Current immunotherapies targeting eosinophils improve outcomes in severe cases.
  • Existing evidence suggests a predominantly detrimental role for eosinophils in asthma.

Purpose of the Study:

  • To review evidence for diverse eosinophil subsets in asthma.
  • To explore distinct functional roles of these eosinophil subsets.
  • To discuss strategies for understanding eosinophil heterogeneity for personalized medicine.

Main Methods:

  • Review of pre-clinical research.
  • Analysis of clinical trial data.
  • Exploration of emerging cellular heterogeneity studies.

Main Results:

  • Evidence suggests eosinophils possess diverse functional roles in asthma.
  • Specific eosinophil subsets may have distinct implications in disease pathology.
  • Current understanding of eosinophils in asthma may be incomplete.

Conclusions:

  • Eosinophil heterogeneity is a critical area for further investigation.
  • Deciphering eosinophil subsets can advance personalized treatment strategies for severe eosinophilic asthma.
  • Future research should focus on identifying and characterizing distinct eosinophil populations.