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Olfactory bulb involvement in Pick's disease.

N Yoshimura1

  • 1Department of Pathology (Neuropathology), Hirosaki University School of Medicine, Japan.

Acta Neuropathologica
|January 1, 1988
PubMed
Summary
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Pick's disease affects olfactory bulb cells, including mitral and tufted cells, with characteristic Pick bodies. This neurodegenerative disease impacts olfactory pathways, showing specific cellular degeneration.

Area of Science:

  • Neuroscience
  • Neuropathology

Background:

  • Pick's disease is a rare neurodegenerative disorder.
  • It is characterized by the presence of Pick bodies and neuronal loss.

Purpose of the Study:

  • To investigate the involvement of the olfactory bulbs and stalks in Pick's disease.
  • To characterize the neuropathological changes in these olfactory structures.

Main Methods:

  • Examination of olfactory bulbs and stalks from a patient with Pick's disease.
  • Histopathological analysis, including silver staining for Pick bodies.
  • Electron microscopy to assess ultrastructural features.

Main Results:

  • Pick bodies were identified in the anterior olfactory nucleus, mitral cells, and tufted cells.

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  • Neuronal loss and astrocytosis were observed in the olfactory bulb.
  • No neurofibrillary tangles or senile plaques were found in the olfactory structures.
  • Ultrastructural analysis confirmed Pick bodies in the olfactory bulb were similar to those in the cerebral cortex and hippocampus.

    • Conclusions:

    • The olfactory bulb, including mitral and tufted cells and the anterior olfactory nucleus, is affected by Pick's disease.
    • The degeneration observed is specific to Pick's disease.
    • Olfactory pathway involvement is a feature of Pick's disease neuropathology.