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Aptamer-based biosensor for detecting carcinoembryonic antigen.

Wenwen Xiang1, Qiuxiang Lv1, Haixia Shi2

  • 1Institute of Life Sciences, Jiangsu University, Zhenjiang, 212013, PR China.

Talanta
|April 13, 2020
PubMed
Summary
This summary is machine-generated.

This review explores advanced aptamer biosensors for detecting carcinoembryonic antigen (CEA), a key cancer marker. These novel biosensors offer a sensitive, cost-effective alternative to traditional immunoassay methods for cancer diagnosis.

Keywords:
AptamerBiosensorCarcinoembryonic antigenNanoparticleTumor marker

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Cancer Biomarkers

Background:

  • Carcinoembryonic antigen (CEA) is a glycoprotein crucial in cell adhesion, normally expressed at low levels in adults but overexpressed in various cancers, notably colorectal cancer.
  • Accurate CEA detection is vital for cancer diagnosis, monitoring, and treatment evaluation.
  • Conventional immunoassay methods for CEA detection are limited by complex instrumentation, high costs, and potential radiation exposure.

Purpose of the Study:

  • To review and classify recent advancements in optical and electrochemical aptamer-based biosensors for CEA detection.
  • To compare the advantages and disadvantages of these emerging biosensor technologies.
  • To highlight the potential of aptamer biosensors as alternatives to traditional CEA testing methods.

Main Methods:

  • Review of literature on optical aptamer biosensors for CEA detection.
  • Review of literature on electrochemical aptamer biosensors for CEA detection.
  • Comparative analysis of sensitivity, selectivity, accuracy, response time, and cost.

Main Results:

  • Aptamer-based biosensors demonstrate high sensitivity, selectivity, and accuracy for CEA detection.
  • Optical and electrochemical aptamer biosensors offer rapid response times and lower costs compared to immunoassays.
  • These biosensors present a promising alternative for clinical CEA monitoring.

Conclusions:

  • Aptamer biosensors represent a significant advancement in the detection of carcinoembryonic antigen (CEA).
  • Optical and electrochemical aptamer biosensors provide sensitive, selective, and cost-effective platforms for cancer biomarker analysis.
  • Further development of aptamer biosensors could revolutionize cancer diagnostics and patient management.