Related Experiment Video
Updated: Dec 24, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
Published on: October 27, 2020
Targeting TGFβ Signalling in Cancer: Toward Context-Specific Strategies
Rhiannon French1, Yuliang Feng1, Siim Pauklin1
1Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Old Road, University of Oxford, Headington, Oxford OX3 7LD, UK.
None:
The transforming growth factor beta (TGFβ) signalling pathway regulates a range of important cellular processes in a context-dependent manner. Recent discoveries have provided important insights into the regulation of the TGFβ pathway and its change from an antitumorigenic to a protumorigenic pathway. These findings may have important implications for cancer stem cell (CSC) functions and therapeutic strategies.
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against...
TGF - β Signaling Pathway
The Tumor Microenvironment
Tumor Immunotherapy
Mitogens and the Cell Cycle
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

