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Updated: Dec 24, 2025

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
Published on: April 28, 2023
Effects of using high-intensity interval training and calorie restriction in different orders on metabolic syndrome:
1Occupational Epidemiology Research Group, National Institute of Occupational Safety and Health, Japan. Kwasaki, Japan; Research Center for Overwork-Related Disorders, National Institute of Occupational Safety and Health, Japan. Kawasaki, Japan.
Objective:
Studies of the effectiveness of high-intensity interval training (HIIT) combined with calorie restriction (CR) are very limited, and the most effective order of intervention is unclear. Therefore, we investigated the impact of time-efficient HIIT with CR intervention on metabolic syndrome (MetS) and the impact of the intervention order on changes in MetS risk factors.
Methods:
Thirty-two participants with MetS underwent an 11-wk intervention program comprising 8 wk of HIIT and 3 wk of CR. Participants were randomly assigned to either the HIIT-then-CR or CR-then-HIIT groups. Thereafter, the CR-then-HIIT group performed a further 8 wk of training once per week after the initial intervention period. Risk factors for MetS and peak oxygen uptake (VO2peak) were assessed during the entire study period.
Results:
During the 11-wk intervention period, body composition, MetS risk factors, and VO2peak significantly improved in both groups. No significant differences in these improvements were attributable to the intervention order; nonetheless, there was a tendency toward larger effect sizes in the CR-then-HIIT group. During the postintervention period (8 wk), a single weekly HIIT session prevented VO2peak reduction in the CR-then-HIIT group (-2.0 ± 7.2%; P = 0.31).
Conclusions:
The time-efficient intervention program with HIIT and CR had a beneficial effect on MetS; however, the intervention order had no influence on the changes in risk factors.
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