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Updated: Dec 24, 2025

Implantation of Osmotic Pumps and Induction of Stress to Establish a Symptomatic, Pharmacological Mouse Model for DYT/PARK-ATP1A3 Dystonia
Published on: September 12, 2020
Medical and Surgical Treatments for Dystonia
1Department of Neurology, Emory University School of Medicine, Suite 6305 Woodruff Memorial Building, Atlanta, GA 30322, USA; Department of Human Genetics, Emory University School of Medicine, Suite 6305 Woodruff Memorial Building, Atlanta, GA 30322, USA.
Abstract:
The dystonias are a large and heterogenous group of disorders characterized by excessive muscle contractions leading to abnormal postures and/or repetitive movements. Their clinical manifestations vary widely, and there are many potential causes. Despite the heterogeneity, helpful treatments are available for the vast majority of patients. Symptom-based therapies include oral medications, botulinum toxins, and surgical interventions. For some subtypes of dystonia, specific mechanism-based treatments are available. Advances in understanding the biological basis for many types of dystonia have led to numerous recent clinical trials, so additional treatments are likely to become available in the very near future.
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