Related Experiment Video
Updated: Dec 24, 2025
09:34
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
Published on: February 9, 2019
9.3K
Nanoparticle Drug Delivery Systems for α-Mangostin
Nasrul Wathoni1, Agus Rusdin1,2, Keiichi Motoyama3
1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia.
Nanotechnology, Science and Applications
|April 14, 2020
Summary
Nanoparticle drug delivery systems significantly enhance alpha-mangostin
Area of Science:
- Pharmacology
- Drug Delivery
- Materials Science
Background:
- Alpha-mangostin, a xanthone from Garcinia mangostana, possesses diverse bioactivities.
- Limitations include poor aqueous solubility and target selectivity.
- Nanoparticle systems offer potential solutions for drug delivery challenges.
Purpose of the Study:
- To review and discuss nanoparticle drug delivery systems for alpha-mangostin.
- To explore methods for improving alpha-mangostin's physicochemical properties and efficacy.
- To assess the impact of various nanoparticle formulations on solubility, release, and targeting.
Main Methods:
- Systematic literature review of Scopus, PubMed, and Google Scholar.
- Analysis of various nanoparticle types: polymeric nanoparticles, nanomicelles, liposomes, solid lipid nanoparticles, nanofibers, and nanoemulsions.
- Evaluation of reported improvements in solubility, controlled release, and targeted delivery.
Main Results:
- Nanomicelle formulation achieved over 10,000-fold increase in alpha-mangostin solubility.
- Polymeric nanoparticles demonstrated targeted delivery and enhanced biodistribution.
- Various nanoparticle systems successfully improved solubility, controlled release, and selectivity.
Conclusions:
- Nanoparticle drug delivery systems are a promising strategy for alpha-mangostin.
- These systems can overcome solubility and selectivity limitations.
- Alpha-mangostin holds potential as a clinical therapeutic agent with nanoparticle enhancement.
Related Concept Videos
01:16Drug Delivery: Overview
652
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
652
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
143
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
143
01:29Drug Delivery: Parenteral Route
1.4K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.4K