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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

Liver toxicity from vitamin A.

Rosanna Fox¹, Nigel Stace¹, Karen Wood¹

¹Department of Gastroenterology & Hepatology Wellington Regional Hospital Wellington New Zealand.

JGH Open : an Open Access Journal of Gastroenterology and Hepatology

|April 14, 2020

Summary

This summary is machine-generated.

A rare case of liver damage from excess vitamin A (hypervitaminosis A) is presented. This occurred in a young woman taking isotretinoin and high doses of vitamin A supplements for over 18 months.

Keywords:

drug‐induced liver injury hepatic inflammation hypervitaminosis A

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Area of Science:

Hepatology
Toxicology
Dermatology

Background:

Hypervitaminosis A, or vitamin A toxicity, is uncommon.
Isotretinoin, a vitamin A derivative, is used for acne treatment.
Concurrent vitamin A supplementation can increase toxicity risk.

Observation:

A 27-year-old female presented with abdominal pain and cholestatic liver enzymes.
Computerized tomography revealed abnormal liver findings.
She had been using isotretinoin and self-prescribed high-dose vitamin A for 18+ months.

Findings:

The patient's presentation was consistent with drug-induced liver injury.
Excessive vitamin A intake, exacerbated by isotretinoin use, is the likely cause.
Hepatic toxicity secondary to hypervitaminosis A is extremely rare.

Implications:

Clinicians should be vigilant for hypervitaminosis A in patients using isotretinoin and vitamin A supplements.
This case highlights the potential dangers of excessive vitamin A intake.
Further research into the synergistic toxicity of isotretinoin and vitamin A is warranted.