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Updated: Dec 24, 2025

Ex Vivo Pressurized Hippocampal Capillary-Parenchymal Arteriole Preparation for Functional Study
Published on: December 18, 2019
Hypoperfusion of the deep capillary plexus associated with acute on chronic cocaine use
William J Carroll1, Nenita Maganti1, Manjot K Gill1
1Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Purpose:
To illustrate a case of decreased perfusion in the deep capillary plexus seen on ocular coherence tomography angiography in a patient with acute on chronic cocaine use.
Observations:
A 69-year-old male who presented with a sudden loss of vision in his right eye following recent use of cocaine. Ocular coherence tomography of the right eye revealed hyperreflectivity within layers of the retina and ocular coherence tomography angiography showed decreased vascular density and flow in the deep capillary plexus.
Conclusions And Importance:
Cocaine use has been associated with systemic and cardiac effects, as well as ocular sequelae. It has been hypothesized to have a role in the pathogenesis of acute macular neuroretinopathy. Here we present the first case of ocular coherence tomography angiography findings of hypoperfusion of the deep capillary plexus in a patient with acute on chronic cocaine use.
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