Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of Anti-Phospholipid Antibodies in Lyme Borreliosis Using In-House Developed ELISAs.

Antibodies (Basel, Switzerland)·2026
Same author

CBD Promotes Structural and Functional Epithelial Restoration and Alleviates Inflammation in a Mouse Model of Interstitial Cystitis.

Pharmaceutics·2026
Same author

Plasma-based treatments regulate seed germination in Cannabis sativa via oxidative status modulation and transcriptional changes.

Plant physiology and biochemistry : PPB·2026
Same author

Interface-governed electromechanical coupling in bioinspired hierarchical piezoelectric poly(L-lactide) architectures.

Materials horizons·2026
Same author

Biosourced Paeonia tenuifolia L. petal-adsorbent for Pb<sup>2+</sup> and methyl violet dye removal: kinetical, isothermal and reusability assays.

Journal of environmental management·2026
Same author

Lipid-phase-modulated interactions of gold nanoparticles with supported vesicular and planar membranes.

Colloids and surfaces. B, Biointerfaces·2026

Related Experiment Video

Updated: Dec 24, 2025

Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model
11:49

Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model

Published on: September 9, 2011

20.9K

Titanium Dioxide Nanotube Arrays for Cardiovascular Stent Applications.

Ita Junkar1, Mukta Kulkarni2, Metka Benčina1

  • 1Department of Surface Engineering and Optoelectronics, Jožef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia.

ACS Omega
|April 14, 2020
PubMed
Summary

This study presents a novel surface treatment for medical stents to prevent blood clots and promote healing. Nanostructuring and plasma modification of titanium surfaces improve biocompatibility for better stent performance.

More Related Videos

Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents
06:55

Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents

Published on: October 26, 2016

9.3K
Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention
11:01

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention

Published on: September 18, 2015

11.9K

Related Experiment Videos

Last Updated: Dec 24, 2025

Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model
11:49

Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model

Published on: September 9, 2011

20.9K
Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents
06:55

Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents

Published on: October 26, 2016

9.3K
Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention
11:01

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention

Published on: September 18, 2015

11.9K

Area of Science:

  • Biomaterials Science
  • Surface Engineering
  • Medical Device Technology

Background:

  • Stent implantation requires surfaces that prevent adverse biological reactions like thrombosis and neointimal hyperplasia.
  • Current stent materials face challenges in balancing anti-fouling properties with endothelial cell support.

Purpose of the Study:

  • To develop and evaluate a titanium surface modification strategy for enhanced stent biocompatibility.
  • To prevent platelet and smooth muscle cell adhesion while promoting endothelial cell growth.

Main Methods:

  • Surface nanostructuring of titanium using electrochemical anodization to create nanotopographies.
  • Chemical surface activation via oxygen plasma treatment of titanium oxide nanotubes.
  • Characterization using SEM, AFM, XPS, and water contact angle measurements.
  • In vitro biological response assessment with endothelial cells, smooth muscle cells, and whole blood.

Main Results:

  • Achieved specific nanotopographies on titanium surfaces.
  • Plasma modification altered surface chemistry and wettability.
  • Demonstrated reduced platelet and smooth muscle cell adhesion and activation.
  • Showcased enhanced growth of human coronary artery endothelial cells on modified surfaces.

Conclusions:

  • Combined nanostructuring and plasma modification of titanium surfaces is a promising approach for implantable medical devices.
  • This surface engineering strategy effectively promotes desired biological responses for improved stent performance and reduced complications.