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Phonophobia and migraine features in patients with definite meniere's disease: Pentad or triad/tetrad?
Alia Saberi1, Shadman Nemati2, Tina Taherzadeh Amlashi3
1Neurosciences Research Center, Neurology Department, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Abstract:
Background: Epidemiological studies have shown different association between migraine and Meniere's disease (MD). Few studies investigated the frequency of phonophobia in MD.Objectives: This study aimed to determine the frequency of phonophobia and other features of migraine in definite MD.Material and Methods: Patients with definite MD and a group of healthy (non-MD, non-vertiginous) control subjects participated. Demographic data and other clinical features of the two diseases recorded. Data analyzed in SPSS software version 20, by qi square and independent T test and logistic regression model.Results: 69 MD patients (average age: 48.87 ± 12.15 years) and 60 control subjects (average age: 47.58 ± 12.05 years) enrolled. The frequency of migraine headache in MD cases was 16% (45% with aura) compared with 5% in control group (three cases; 2 without and 1 with aura) (p < .001). Family history of migraine was the only determinant of the presence of migraine in MD (p = .001, OR = 15.625, 95%CI: 2.94-88.33). The frequency of phonophobia in MD was very high (88.4%: 54.5% in migraine subgroup and 89.6% in non-migraine cases) and without significant relation to existence of migraine, in contrast to photophobia and osmophobia (p = .064).Conclusions: The frequency of migraine in MD is higher than normal subjects. Phonophobia may be an independent symptom in MD.
Insights
Migraine is more common in Meniere
Area of Science:
- Neurology
- Otolaryngology
Background:
- Migraine and Meniere's disease (MD) show varied associations in epidemiological studies.
- Limited research exists on phonophobia frequency within Meniere's disease.
Purpose of the Study:
- To determine the frequency of phonophobia and migraine features in patients with definite Meniere's disease.
- To compare these features against a healthy control group.
Main Methods:
- Involved 69 patients with definite Meniere's disease and 60 healthy controls.
- Demographic and clinical data were collected and analyzed using SPSS software (chi-square, independent T test, logistic regression).
Main Results:
- Migraine prevalence was significantly higher in Meniere's disease patients (16%) compared to controls (5%) (p < .001).
- Family history of migraine was the sole predictor for migraine presence in Meniere's disease (OR = 15.625).
- Phonophobia occurred in 88.4% of Meniere's disease patients, irrespective of migraine status, unlike photophobia and osmophobia.
Conclusions:
- The prevalence of migraine is elevated in individuals with Meniere's disease.
- Phonophobia may represent an independent symptom in Meniere's disease, separate from migraine.
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