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Related Concept Videos

Compact Bone01:27

Compact Bone

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Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
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Spongy Bone01:09

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All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
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Bone Markings01:26

Bone Markings

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Bones have various surface features that help form joints and attach to other soft tissues. Depending on the function, bone markings are categorized into articulating projections, processes for attachment, depressions, and openings.
Articulating Projections
Articulating projections are found where two bones meet to form a joint. These structures are usually found at the ends of bones. The largest articulation is a rounded projection called the head, supported by a narrow neck at the ends of...
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Bone as Supporting Connective Tissue01:23

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Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
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Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
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Bone involvement in classic Kaposi's sarcoma.

Athanasia Tourlaki1, Francesca Germiniasi1, Roberta Mancuso2

  • 1Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, U.O. Dermatologia, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico.

European Journal of Dermatology : EJD
|April 14, 2020
PubMed
Summary

Classic Kaposi's sarcoma (KS), a rare skin cancer, can exceptionally affect bone. This study identified three male patients with classic KS who developed bone involvement, highlighting the need for considering bone pain in KS patients.

Keywords:
HHV8Kaposi's sarcoma (KS)anaplastic KSbone

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Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Classic Kaposi's sarcoma (KS) is a rare angioproliferative neoplasm typically affecting the skin of immunocompetent elderly men.
  • Bone involvement in classic KS is exceptionally rare, making its diagnosis and management challenging.

Purpose of the Study:

  • To identify and characterize patients with classic Kaposi's sarcoma who developed bone involvement.
  • To analyze the clinical presentation, diagnostic methods, treatment, and outcomes of bone involvement in classic KS.

Main Methods:

  • Retrospective analysis of a departmental database of classic Kaposi's sarcoma patients.
  • Comparison of identified cases with existing literature on KS bone involvement.
  • Review of clinical data, imaging (MRI), biopsy results, and human herpesvirus 8 (HHV8) genotyping.

Main Results:

  • Three out of 1,196 (0.25%) patients with classic KS developed bone involvement.
  • All affected patients were male, with an average age of 81.3 years at bone involvement onset.
  • Biopsy-proven anaplastic KS affected lower limb bones; MRI revealed osteolytic lesions or solid tumors, with HHV8 subtypes A and C identified in two patients.

Conclusions:

  • Bone involvement is a rare but significant complication of classic Kaposi's sarcoma.
  • Clinicians should consider bone involvement in patients with known KS presenting with bone pain.