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Related Experiment Video

Updated: Dec 24, 2025

Long-term Silencing of Intersectin-1s in Mouse Lungs by Repeated Delivery of a Specific siRNA via Cationic Liposomes. Evaluation of Knockdown Effects by Electron Microscopy
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Liposome Circulation Time is Prolonged by CD47 Coating.

Seyed Mohammad Gheibi Hayat1, Mahmoud R Jaafari2,3, Mahdi Hatamipour3

  • 1Department of Medical Biotechnology, Faculty Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Protein and Peptide Letters
|April 14, 2020
PubMed
Summary
This summary is machine-generated.

A novel CD47 mimicry peptide enhances nanoliposome circulation time, reducing macrophage clearance for improved drug delivery. This peptide coating decreases drug accumulation in non-target organs, potentially lowering toxicity.

Keywords:
CD47Liposomehalf-lifekineticmacrophagephagocytosis

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • Biodegradable nanoparticles are promising drug delivery vehicles but face rapid clearance by macrophages.
  • Polyethylene glycol (PEG) is commonly used to create "stealth" nanoparticles, but has limitations.
  • The CD47 receptor acts as a "self" marker, inhibiting phagocytosis.

Purpose of the Study:

  • To investigate a CD47 mimicry peptide as an alternative to PEG for creating "stealth" nanoliposomes.
  • To evaluate the effect of CD47 mimicry peptide coating on nanoliposome circulation time and biodistribution.
  • To assess the potential of CD47 mimicry peptide to reduce drug accumulation in non-target tissues.

Main Methods:

  • Doxorubicin-loaded liposomes were formulated with varying percentages of CD47 mimicry peptide.
  • Polyethylene glycol (PEG)-functionalized liposomes served as a control.
  • Liposomal formulations were administered intravenously to mice, with serum and tissue samples analyzed for doxorubicin concentration.

Main Results:

  • CD47 mimicry peptide significantly increased the circulation time of doxorubicin-loaded nanoliposomes compared to PEG.
  • Unwanted accumulation of doxorubicin in the liver, spleen, kidney, and heart was substantially reduced.
  • Nanoliposome surface modification with CD47 mimicry peptide improved drug residence time in circulation.

Conclusions:

  • CD47 mimicry peptide is an effective alternative to PEG for enhancing nanoliposome stealth properties.
  • This approach improves drug circulation time and reduces accumulation in non-target organs.
  • CD47 mimicry peptide-coated nanoliposomes hold potential for reducing drug-induced toxicity.