Related Experiment Video

Updated: Dec 24, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.8K

Prognosis of incidental left bundle branch block

Abbasin Zegard1, Osita Okafor1, Joseph de Bono2

  • 1Department of Cardiology, Aston Medical Research Institute, Aston Medical School, Aston University, Birmingham B15 2TH, UK.

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
|April 15, 2020
PubMed

Insights

Cardiovascular magnetic resonance (CMR) risk-stratifies patients with incidental left bundle branch block (iLBBB). Abnormal CMR findings indicate poor outcomes, while normal findings suggest comparable survival to controls.

Area of Science:

  • Cardiology
  • Medical Imaging

Background:

  • Incidental left bundle branch block (iLBBB) frequently leads to cardiology referrals, often with prognostic uncertainty.
  • Current risk stratification methods for iLBBB lack definitive prognostic value.

Purpose of the Study:

  • To assess the utility of cardiovascular magnetic resonance (CMR) in risk stratification for patients with iLBBB.
  • To determine if CMR can differentiate prognosis in patients with iLBBB.

Main Methods:

  • A cohort of 193 patients with iLBBB underwent CMR.
  • Patients were categorized into abnormal (iLBBBCMR+) or normal (iLBBBCMR-) CMR phenotypes.
  • Clinical events were tracked over a median of 3.75 years, with outcomes compared to a control group (n=107).

Main Results:

  • 56.9% of iLBBB patients had an abnormal CMR phenotype (iLBBBCMR+).
  • iLBBBCMR+ patients exhibited significantly higher total mortality and major adverse cardiac events (MACEs) compared to controls.
  • iLBBBCMR- patients had similar total mortality to controls but increased MACEs.
  • Myocardial fibrosis and left ventricular ejection fraction (LVEF) ≤50% were independent predictors of mortality in iLBBB patients, with a combined additive effect.

Conclusions:

  • Patients with iLBBB and abnormal CMR findings (iLBBBCMR+) face poor outcomes.
  • Patients with iLBBB and normal CMR findings (iLBBBCMR-) have survival comparable to controls, though MACE risk is elevated.
  • CMR is crucial for risk-stratifying iLBBB patients, identifying those at higher risk who may benefit from further intervention.
Abstract

Keywords:
Cardiovascular magnetic resonanceLeft bundle branch blockMortality

More Related Videos

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA13:10

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA

Published on: April 24, 2017

19.1K
Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology10:46

Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology

Published on: May 26, 2015

13.7K

Related Concept Videos

Dysrhythmias IV: Characteristics of Bradyarrhythmias01:18

Dysrhythmias IV: Characteristics of Bradyarrhythmias

Bradyarrhythmias are cardiac rhythm disorders characterized by a slower-than-normal heart rate, typically defined as fewer than 60 beats per minute. Some of which are discussed here:Sinus BradycardiaSinus bradycardia presents a heart rate lower than 60 beats per minute, with a regular rhythm originating from the SA node. The ECG typically shows normal P waves preceding each QRS complex, a normal PR interval (0.12 to 0.20 seconds), and a normal QRS duration (0.06 to 0.10 seconds).First-Degree AV...
380
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
154
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
283
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
297
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
298
Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
242