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Biomaterials and Microfluidics for Liver Models.

Alain da Silva Morais1,2, Joaquim M Oliveira3,4,5, Rui L Reis3,4,5

  • 13B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, Guimarães, Portugal. alain.morais@i3bs.uminho.pt.

Advances in Experimental Medicine and Biology
|April 15, 2020
PubMed
Summary
This summary is machine-generated.

Tissue engineering advances have led to sophisticated biomaterial scaffolds for creating liver micro-tissues. These engineered liver constructs are crucial for developing advanced cell-based assays and regenerative medicine strategies.

Keywords:
BiomaterialsDecellularized matricesHydrogelsLiver modelsMicrofluidicsNatural polymers

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Hepatology

Background:

  • Significant advancements in tissue engineering have focused on biomaterial scaffolds for engineered tissue constructs.
  • Early efforts involved seeding cells onto scaffolds, with innovative manufacturing enabling preformed scaffold development.
  • Applying scaffold technology to liver constructs presents unique challenges in tissue engineering.

Purpose of the Study:

  • To review biomaterials used in developing in vitro liver constructs.
  • To describe microfluidic-based models for liver regenerative medicine.
  • To highlight progress in mimicking liver parenchyma structure-function interactions.

Main Methods:

  • Engineering sophisticated biomaterial scaffolds.
  • Utilizing advanced liver-cell sources.
  • Implementing advanced in vitro culture techniques.
  • Developing microfluidic-based models.

Main Results:

  • Successful creation of microscale tissue (micro-tissue) constructs mimicking liver parenchyma.
  • Upgrading micro-tissue constructs into cell-based assays for toxicity testing.
  • Demonstration of microfluidic models' promise for liver regenerative medicine.

Conclusions:

  • Biomaterial scaffolds and microfluidic technologies are key to developing in vitro liver constructs.
  • Engineered liver micro-tissues are vital for drug toxicity testing and regenerative medicine.
  • Continued innovation in biomaterials and microfluidics will advance liver tissue engineering.