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Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Coronary Artery Disease I: Introduction01:30

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Non-coding RNAs and Coronary Artery Disease.

Alejandro Cardona-Monzonís1, José Luis García-Giménez1, Salvador Mena-Mollá2

  • 1Center for Biomedical Network Research-Instituto de Salud Carlos III. Department of Physiology, School of Medicine, University of Valencia and INCLIVA Biomedical Research Institute, Valencia, Spain.

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Summary

Circulating non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), show promise as biomarkers for coronary artery disease (CAD). These molecules can help detect CAD and predict patient outcomes.

Keywords:
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Area of Science:

  • Genetics and Molecular Biology
  • Cardiovascular Medicine
  • Biomarker Discovery

Background:

  • Coronary artery disease (CAD) is a major global health concern.
  • Non-coding RNAs (ncRNAs) regulate gene expression and are implicated in disease pathogenesis.
  • ncRNAs, such as miRNAs, lncRNAs, and circRNAs, exist in circulation and can serve as disease biomarkers.

Purpose of the Study:

  • To review potential non-coding RNA biomarkers for coronary artery disease (CAD).
  • To highlight the role of circulating ncRNAs in CAD detection and prognosis.
  • To provide a comprehensive list of miRNA, lncRNA, and circRNA candidates for CAD biomarker research.

Main Methods:

  • Literature review of studies investigating non-coding RNAs in coronary artery disease.
  • Analysis of circulating ncRNAs (miRNA, lncRNA, circRNA) as potential CAD biomarkers.
  • Compilation of a list of ncRNAs associated with CAD presence and outcome.

Main Results:

  • Circulating ncRNAs have demonstrated potential in identifying CAD.
  • Specific miRNAs, lncRNAs, and circRNAs are associated with CAD.
  • These ncRNAs may offer insights into disease progression and patient outcomes.

Conclusions:

  • Circulating non-coding RNAs represent a promising avenue for novel CAD biomarkers.
  • Further research into miRNA, lncRNA, and circRNA biomarkers could advance precision medicine for CAD.
  • These RNA molecules hold potential for non-invasive CAD diagnosis and risk stratification.