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Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging

Hui Ye1,2, Shamsideen A Ojelade2, David Li-Kroeger1

  • 1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.

Elife
|April 15, 2020
PubMed
Summary

The retromer protein Vps29 is essential for brain function in aging flies, regulating protein recycling and neuronal health. Its absence causes mislocalization and endolysosomal dysfunction, impacting survival and locomotion.

Keywords:
D. melanogasterDrosophilaRab7TBC1D5VPS29VPS35cell biologyendolysosomal traffickingneuroscience

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