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Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...

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Sugar-Based Aggregation-Induced Emission Luminogens: Design, Structures, and Applications.

Yijia Wang^1,2, Jingyi Nie^1,2, Wen Fang^1,2

¹MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.

Chemical Reviews

|April 15, 2020

Summary

This summary is machine-generated.

Aggregation-induced emission luminogens (AIE-gens) offer advanced applications in detecting and imaging sugar-based biomaterials. This review highlights their use in polysaccharides, oligosaccharides, and monosaccharides, paving the way for novel bioconjugates.

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Area of Science:

Biochemistry
Biomaterials Science
Carbohydrate Chemistry

Background:

Bioactive saccharides are crucial in biological systems and biomaterials.
Aggregation-induced emission luminogens (AIE-gens) are valuable tools for detection, tracing, and imaging.
AIE-gens enhance the study of sugar-based biomaterials and biological sciences.

Purpose of the Study:

To review the applications of AIE molecules in sugar-based biomaterials.
To focus on saccharide detection, stimuli-responsive materials, bioimaging, and AIE mechanisms.
To explore the potential of AIE-gens in polysaccharide, oligosaccharide, and monosaccharide research.

Main Methods:

Literature review of existing research on AIE molecules and sugar-based biomaterials.
Categorization of applications based on saccharide type: polysaccharide, oligosaccharide, and monosaccharide.
Analysis of AIE mechanisms and their role in material properties and biological detection.

Main Results:

AIE-gens have been successfully applied in detecting and imaging various sugar-based biomaterials.
The review covers applications in polysaccharides, oligosaccharides, and monosaccharides.
Significant progress has been made in understanding AIE mechanisms within these systems.

Conclusions:

Sugar-based AIE bioconjugates show promising potential for future applications.
Further research is needed to explore untapped areas like mucopolysaccharides and glycoproteins.
The integration of AIE technology with diverse saccharide structures offers exciting avenues for biological and material science advancements.