Prevalence of Human rhinovirus infection in young children with acute wheezing

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Published on: January 21, 2018

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Hanaa I Rady1, Amani El Kholy2

  • 1Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.

The Gazette of the Egyptian Paediatric Association
|April 15, 2020
PubMed

Insights

Human Rhinovirus (HRV) was the second most common viral infection in children experiencing acute wheezing episodes. This viral infection showed a higher mortality rate compared to other respiratory viruses.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Respiratory Medicine

Background:

  • Recurrent wheezing is a significant cause of chronic childhood illness.
  • Identifying the causative agents of acute wheezing is crucial for effective management.
  • Respiratory infections are common triggers for wheezing episodes in young children.

Purpose of the Study:

  • To determine the prevalence of Human Rhinovirus (HRV) in children with acute wheezing.
  • To investigate the association between HRV infection and wheezing episodes following respiratory illness.
  • To compare the prevalence and outcomes of HRV with other respiratory viruses in this population.

Main Methods:

  • A study involving 200 children aged 2 months to 5 years with acute wheezing.
  • Clinical history, examination, and chest X-rays were performed on all participants.
  • Nasopharyngeal and oropharyngeal swabs were analyzed using PCR to detect HRV and other viruses.

Main Results:

  • Viral infections were detected in 81.5% of the children studied.
  • Respiratory Syncytial virus (RSV) was the most common, found in 49.5% of cases.
  • Human Rhinovirus (HRV) was identified in 43.5% of cases, making it the second most prevalent virus.

Conclusions:

  • HRV is a significant contributor to acute wheezing in children, particularly following respiratory illness.
  • HRV prevalence peaked in winter, correlating with increased recurrence and a high mortality rate of 43.7%.
  • HRV warrants consideration in the differential diagnosis and management of acute wheezing in pediatric populations.
Abstract

Keywords:
AsthmaRhinovirus infectionWheezes

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