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Updated: Dec 24, 2025

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
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[HMGB1: a link between innate and adaptive immunity].

Stéphanie Barnay-Verdier1, Vincent Maréchal1, Chloé Borde1

  • 1Centre de recherches biomédicales des Cordeliers - INSERM, Université Pierre-et-Marie-Curie - Université Paris Descartes, 15, rue de l'Ecole-de-Médecine, 75270 Paris cedex 06.

Revue Francophone Des Laboratoires : RFL
|April 15, 2020
PubMed
Summary

High Mobility group box 1 (HMGB1) protein, released outside cells, amplifies inflammation and aids tissue repair. Extracellular HMGB1 also drives inflammatory and infectious diseases.

Keywords:
DAMPHMGB1cellular deathcytokineimmune responseinflammation

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Area of Science:

  • Molecular Biology
  • Immunology
  • Cell Biology

Context:

  • High Mobility group box 1 (HMGB1) protein, initially identified as a DNA-binding structural co-factor.
  • HMGB1 is released extracellularly upon immune activation or cell necrosis.
  • Extracellular HMGB1 functions as a soluble mediator coordinating crucial cellular events.

Purpose:

  • To elucidate the dual role of HMGB1 in biological processes.
  • To highlight HMGB1's function in inflammation, immunity, and tissue repair.
  • To underscore HMGB1's contribution to inflammatory and infectious disease pathogenesis.

Summary:

  • Extracellular HMGB1 orchestrates inflammation amplification, early immune responses, and tissue repair.
  • Despite its reparative roles, extracellular HMGB1 acts as a pro-inflammatory cytokine.
  • HMGB1 contributes significantly to the pathology of various inflammatory and infectious conditions.

Impact:

  • Provides insights into HMGB1's complex role in health and disease.
  • Identifies HMGB1 as a potential therapeutic target for inflammatory disorders.
  • Enhances understanding of immune system regulation and tissue homeostasis.