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Updated: Dec 24, 2025
Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
Published on: July 24, 2016
[Day-care centers: Sites of viral contact]
J Brouard1,2, A Vabret3,2, J Dina3,2
1Service de pédiatrie, CHU de Caen, avenue Côte-de-Nacre, 14033 Caen, France.
Insights
Young children in daycare experience frequent infections, particularly respiratory and gastrointestinal. Early daycare infections can predict later recurrent illness and impact the respiratory and digestive microbiota.
Area of Science:
- Pediatrics
- Infectious Diseases
- Microbiology
Context:
- Young infants in daycare settings are prone to recurrent respiratory and gastrointestinal infections.
- The early months of daycare attendance are critical for infection risk and subsequent health outcomes.
- Daycare environments influence infection patterns, with potential long-term health implications.
Purpose:
- To explore the long-term impact of infections acquired in daycare settings.
- To investigate the relationship between early daycare infections and recurrent infectious episodes.
- To understand the complex interplay between viral infections, asthma, and the microbiota.
Summary:
- Infants in daycare face frequent viral infections affecting respiratory and gastrointestinal systems.
- Early infections in daycare are linked to later recurrent episodes and asthma exacerbation.
- Recurrent infections can lead to antibiotic overuse, promoting antimicrobial resistance and altering microbiota.
Impact:
- Highlights the need for prospective studies on long-term health effects of daycare infections.
- Underscores the complex bidirectional relationship between viral infections and asthma.
- Emphasizes the consequences of antibiotic overuse on microbiota and antimicrobial resistance.
Abstract:
It is well known that young infants attending day-care centers are subjected to repeated infectious episodes, with a tendency to involve the respiratory and gastrointestinal tracts. Their long-term impact is difficult to assess because there are few relevant prospective studies. The risk of infection is influenced in part by the structure of the day-care center, and it is more important in the early months of attending and linked to later recurrent infectious episodes. Causal links between viral infection and asthma are complex. Viral infections increase the risk of asthma exacerbation but the presence of asthma also increases the risk of severe responses to a viral infection. While infections acquired in this environment are mainly viral, their recurrence can lead to excessive use of antibiotics which promote antimicrobial resistance with an impact on the digestive or respiratory microbiota.
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