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Updated: Dec 24, 2025

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
11:17

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays

Published on: January 7, 2016

17.0K

A glimpse at growth hormone-releasing hormone cosmos

Nektarios Barabutis1

  • 1School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA, USA.

Clinical and Experimental Pharmacology & Physiology
|April 15, 2020
PubMed

Insights

Growth hormone-releasing hormone (GHRH) impacts P53 and unfolded protein response. GHRH antagonists may manage acute lung injury and acute respiratory distress syndrome.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Pulmonology

Background:

  • Growth hormone-releasing hormone (GHRH), a hypothalamic neuropeptide, regulates anterior pituitary growth hormone secretion.
  • Emerging evidence indicates GHRH possesses growth factor activities in various experimental malignancies.
  • GHRH antagonists counteract these activities and support lung endothelial barrier integrity.

Discussion:

  • This study investigates GHRH's role in regulating P53 and the unfolded protein response.
  • GHRH antagonists suppress inflammatory pathways and induce the endothelial defender P53.
  • The research explores the mechanistic link between GHRH, P53, and cellular stress responses.

Key Insights:

  • GHRH influences the P53 pathway and unfolded protein response.
  • GHRH antagonists demonstrate potential in preserving lung endothelial barrier function.
  • Suppression of inflammatory pathways is a key mechanism of GHRH antagonist action.

Outlook:

  • GHRH antagonists show promise for managing acute lung injury.
  • Therapeutic strategies targeting GHRH may offer new treatments for acute respiratory distress syndrome.
  • Further research is warranted to explore the clinical application of GHRH antagonists in critical care settings.
Keywords:
P53endocrinologyendotheliumgrowth factorsinflammation

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