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The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
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The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

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Multidrug resistant tuberculosis treatment outcome in children in developing and developed countries: A systematic

Habteyes Hailu Tola1, Khalid Jamal Khadoura2, Worku Jimma3

  • 1Department of Epidemiology and Biostatistics, School of Public Health, Tehran University Medical, Tehran, Iran; Tuberculosis/HIV Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|April 15, 2020
PubMed

Insights

Treatment success for multidrug-resistant tuberculosis (MDR-TB) in children is achievable globally. While developed nations show higher success rates, ongoing improvements in pediatric MDR-TB programs are crucial for all regions.

Area of Science:

  • Pediatric infectious diseases
  • Global health
  • Tuberculosis research

Background:

  • Multidrug-resistant tuberculosis (MDR-TB) poses a significant global health challenge, particularly in pediatric populations.
  • Understanding treatment outcome disparities between developing and developed countries is essential for equitable healthcare delivery.

Purpose of the Study:

  • To compare and contrast treatment outcomes for pediatric MDR-TB between developing and developed countries.
  • To analyze pooled data on treatment success, death, failure, and loss to follow-up.

Main Methods:

  • Systematic review and meta-analysis of published English articles.
  • Searched major electronic databases (PubMed/Medline, EMBASE, Scopus, Web of Science).
  • Utilized a random-effects meta-analysis model to pool data from 17 studies involving 1,343 children.

Main Results:

  • Overall pooled treatment success for pediatric MDR-TB was 77.0%.
  • Treatment success was higher in developed countries (87.0%) compared to developing countries (73.0%).
  • Pooled rates for treatment failure (3.0%), death (8.0%), and loss to follow-up (10.0%) were also determined.

Conclusions:

  • Current MDR-TB drugs demonstrate effectiveness in treating children in both developing and developed countries.
  • Enhancing MDR-TB treatment programs is vital for maximizing successful outcomes.
  • Further research into pediatric MDR-TB treatment outcomes is needed to address evidence gaps.
Abstract

Keywords:
ChildrenMultidrug ResistanceOutcomeTreatmentTuberculosis

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