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Related Experiment Video

Updated: Dec 24, 2025

Transcranial Direct Current Stimulation and Simultaneous Functional Magnetic Resonance Imaging
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Transcranial Direct Current Stimulation and Simultaneous Functional Magnetic Resonance Imaging

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Modeling transcranial electrical stimulation in the aging brain.

Aprinda Indahlastari1, Alejandro Albizu1, Andrew O'Shea1

  • 1Department of Clinical and Health Psychology, Department of Neuroscience, Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.

Brain Stimulation
|April 15, 2020
PubMed
Summary
This summary is machine-generated.

Brain atrophy in older adults reduces transcranial electrical stimulation (tES) current delivery. This study shows that adjusting tES parameters based on individual brain atrophy may optimize treatment outcomes in the aging population.

Keywords:
AgingBrain atrophyFinite element modeltDCStES

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Gerontology

Background:

  • Transcranial electrical stimulation (tES) outcomes vary, potentially due to current delivery efficiency.
  • Brain atrophy, common in aging, may impede tES current flow to the brain.
  • Computational modeling is crucial for predicting tES current distribution within the brain.

Purpose of the Study:

  • To investigate tES field distribution in healthy older adults using computational models.
  • To analyze the relationship between tES current, brain atrophy, and age in an elderly cohort.
  • To establish the largest dataset to date for tES modeling in healthy older adults.

Main Methods:

  • Individualized head models were created for 587 healthy older adults (mean age 73.9 years).
  • Two electrode montages (F3-F4, M1-SO) with 2 mA input current were simulated using ROAST.
  • A customized template (UFAB-587) was used for spatial normalization and analysis of field measures, atrophy, and age.

Main Results:

  • Computed tES field measures showed an inverse correlation with brain atrophy (R² = 0.0829, p < 1.14e-12).
  • Age negatively correlated with tES field patterns in specific brain regions like the DLPFC and precentral gyrus.
  • Mediation analysis indicated that the brain-to-cerebrospinal fluid (CSF) ratio partially explains the age-related decline in current density.

Conclusions:

  • Increasing brain atrophy significantly reduces the amount of tES current reaching the brain in older adults.
  • Modifying tES stimulation parameters based on individual atrophy levels may be necessary for effective treatment.
  • These findings can guide future tES applications and parameter optimization for healthy aging populations.