Autonomic and Cognitive Function Response to Normobaric Hyperoxia Exposure in Healthy Subjects. Preliminary Study

Area of Science:

• Neuroscience
• Cardiovascular Physiology
• Biochemistry

Background:

• Investigates the novel application of high-flow oxygen therapy within a normobaric chamber.
• Examines multifaceted effects on cognitive, biochemical, cardiovascular, and autonomic systems.
• Addresses a gap in understanding normobaric therapy's impact on human physiology.

Purpose of the Study:

• To evaluate the effects of repeated normobaric chamber exposures on cognitive performance.
• To assess changes in oxidative stress markers and neurotrophin levels.
• To determine the impact on cardiovascular and autonomic nervous system function.

Main Methods:

• 17 healthy volunteers underwent ten 2-hour exposures in a normobaric chamber.
• Cognitive function assessed using Trail Making Test (TMT), California Verbal Learning Test (CVLT), Digit Symbol Substitution Test (DSST), and Digit Span (DS).
• Biochemical markers, fatigue (Fatigue Severity Scale), and cardiovascular/autonomic function (Task Force Monitor) were measured pre- and post-intervention.

Main Results:

• Significant improvements observed in TMT A and B, CVLT Long Delay Free Recall, and reduced fatigue.
• Biochemical analysis revealed decreased malondialdehyde and increased Cu Zn superoxide dismutase, Neurotrophin 4, and brain-derived neurotrophic factor (BDNF).
• Enhanced baroreceptor function and a notable increase in nitric oxide synthase 2 and Club cell secretory protein were recorded.

Conclusions:

• Normobaric chamber exposures positively impact cognitive processing speed, memory, and baroreceptor function.
• Therapy influences neurotrophic factor levels and modulates oxidative stress responses.
• Further research is warranted to confirm safety and efficacy, including physician oversight.