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Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Oncosurgery in older patients.

Martin Oliverius, Jan Gojda, Jan Hajer

    Casopis Lekaru Ceskych
    |April 16, 2020
    PubMed
    Summary

    Elderly patients undergoing complex hepatopancreatobiliary surgery can achieve good outcomes with careful patient selection and prerehabilitation. Comprehensive geriatric assessments improve postoperative results for older adults.

    Keywords:
    complex geriatric assessmentelderlyfrailtyhepatopancreatobiliary diseasesliver surgerymorbiditymortality.pancreatic carcinomapre-rehabilitation

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    Area of Science:

    • Geriatric Medicine
    • Surgical Oncology
    • Gastroenterology

    Background:

    • Population aging increases the need for surgery in elderly patients.
    • Chronological age alone is insufficient for surgical indication; objective assessments are crucial.
    • Complex geriatric examinations optimize preoperative evaluation for better outcomes.

    Purpose of the Study:

    • To evaluate perioperative morbidity and mortality in elderly patients undergoing hepatopancreatobiliary procedures.
    • To assess the impact of prerehabilitation on postoperative outcomes in this cohort.

    Main Methods:

    • Retrospective analysis of prospectively collected data from 2015 to March 2019.
    • Inclusion of 245 pancreatic and 156 hepatic procedures in elderly patients.
    • Morbidity and mortality assessed within 75 days post-surgery, using Clavien-Dindo classification.

    Main Results:

    • Correct surgical indication in elderly patients leads to acceptable morbidity and mortality rates.
    • Prerehabilitation, implemented since 2018, has shown improved postoperative outcomes.
    • Comprehensive geriatric assessment aids in optimizing surgical candidacy.

    Conclusions:

    • Elderly patients can safely undergo hepatopancreatobiliary surgery with appropriate evaluation.
    • Prerehabilitation is a valuable strategy for enhancing recovery in older surgical patients.
    • Holistic geriatric assessment is key to successful surgical outcomes in aging populations.