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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.0K
Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Mesenchymal Stem Cells Attenuate Diabetic Nephropathy by Suppressing the ERK-Ferroptosis-ROS Axis.

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Related Experiment Video

Updated: Dec 24, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

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Stem Cell-Based Therapy for Coronavirus Disease 2019.

Robert Chunhua Zhao1

  • 1Department of Cell Biology, School of Life Sciences, Shanghai University, Shanghai, PR China.

Stem Cells and Development
|April 16, 2020
PubMed
Summary

Mesenchymal stem cell transplantation offers a promising alternative therapy for COVID-19. This approach could be crucial in combating the global health emergency caused by SARS-CoV-2.

Area of Science:

  • Immunology
  • Regenerative Medicine
  • Virology

Background:

  • The novel coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, emerged as a global health crisis in late 2019.
  • As of April 9, 2020, the pandemic had infected over 1.4 million people worldwide, with no confirmed effective antiviral treatments or vaccines.
  • The urgent need for alternative therapeutic strategies for COVID-19 is evident.

Purpose of the Study:

  • To propose mesenchymal stem cell transplantation as a novel and promising therapeutic approach for COVID-19.
  • To highlight the potential benefits of stem cell therapy in managing the severe respiratory and systemic complications associated with SARS-CoV-2 infection.

Main Methods:

  • This commentary discusses the potential application of mesenchymal stem cell (MSC) transplantation.
Keywords:
COVID-19clinical trialtransplantation

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  • The discussion is based on the known immunomodulatory and regenerative properties of MSCs.

    • Main Results:

    • Mesenchymal stem cells possess anti-inflammatory and tissue-repair capabilities.
    • These properties suggest MSCs could mitigate the cytokine storm and lung damage characteristic of severe COVID-19.

    Conclusions:

    • Mesenchymal stem cell transplantation presents a viable and promising alternative therapeutic strategy for COVID-19.
    • Further research and clinical trials are warranted to validate the efficacy and safety of MSC therapy in treating patients with SARS-CoV-2 infection.