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Updated: Dec 24, 2025

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
Modular continuous flow synthesis of orthogonally protected 6-deoxy glucose glycals
Subbarao Yalamanchili1, Tu-Anh V Nguyen1, Nicola L B Pohl2
1Department of Chemistry, Tufts University, 62 Talbot Ave, Medford, MA 02145, USA. Clay.Bennett@tufts.edu.
Abstract:
An efficient, modular continuous flow process towards accessing two orthogonally protected glycals is described with the development of reaction conditions for several common protecting group additions in flow, including the addition of benzyl, naphthylmethyl and tert-butyldimethylsilyl ethers. The process affords the desired target compounds in 57-74% overall yield in just 21-37 minutes of flow time. Furthermore, unlike batch conditions, the flow processes avoided the need for active cooling to prevent unwanted exotherms and required shorter reaction times.
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