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Chimeric Humanized Vasculature and Blood: The Intersection of Science and Ethics
Daniel J Garry1, Arthur L Caplan2, Mary G Garry1
1Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA; Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA; Regenerative Medicine and Sciences Program, Paul and Sheila Wellstone Muscular Dystrophy Center, University of Minnesota, 2231 6(th) Street SE (CCRB 4-146), Minneapolis, MN 55455, USA.
Abstract:
The only curative therapy for diseases such as organ failure is orthotopic organ transplantation. Organ transplantation has been limited due to the shortage of donor organs. The huge disparity between those who need and those who receive transplantation therapy drives the pursuit of alternative treatments. Therefore, novel therapies are warranted. Recent studies support the feasibility of generating human-porcine chimeras that one day would provide humanized vasculature and blood for transplantation and serve as important research models. The ethical issues they raise require open discussion and dialog lest promising lines of inquiry flounder due to unfounded fears or compromised public trust.
