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Galectin-3 Is Associated with Cardiovascular Events in Post-Acute Coronary Syndrome Patients with Type-2 Diabetes
A Lorenzo-Almorós1,2, A Pello3,4, Á Aceña3,4
1Department of Internal Medicine, IIS-Fundación Jiménez Díaz, 28040 Madrid, Spain.
In patients with coronary artery disease, galectin-3 predicts cardiovascular events in those with type-2 diabetes. In contrast, monocyte chemoattractant protein-1 and N-terminal fragment of brain natriuretic peptide predict events in non-diabetic patients.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Biomarker Discovery
Background:
- Type-2 diabetes mellitus (T2DM) accelerates atherosclerosis, increasing cardiovascular event risk.
- Predictive biomarkers for cardiovascular events in T2DM patients with coronary artery disease (CAD) are limited.
Purpose of the Study:
- To investigate the predictive value of galectin-3, monocyte chemoattractant protein-1 (MCP-1), and N-terminal fragment of brain natriuretic peptide (NT-proBNP) for cardiovascular events in CAD patients with and without T2DM.
Main Methods:
- A cohort of 964 CAD patients was followed, with baseline plasma levels of galectin-3, MCP-1, and NT-proBNP measured.
- Primary outcome was a composite of acute ischemia, heart failure, or death. Secondary outcomes included individual components.
Main Results:
- T2DM patients (n=232) exhibited higher MCP-1 and galectin-3 levels compared to non-diabetic patients.
- Galectin-3 levels predicted the primary outcome in T2DM patients (HR 1.57), while MCP-1 and NT-proBNP predicted it in non-diabetic patients (HR 1.23 and 1.21, respectively).
- Galectin-3 was the sole biomarker predicting acute ischemic events and heart failure/death in T2DM patients.
Conclusions:
- Galectin-3 is a valuable biomarker for predicting cardiovascular events in CAD patients with T2DM.
- MCP-1 and NT-proBNP are associated with cardiovascular events in CAD patients without T2DM.
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