A Revised Point-to-Point Calibration Approach with Adaptive Errors Correction to Weaken Initial Sensitivity of...

Area of Science:

• Biomedical Engineering
• Cardiovascular Technology
• Medical Device Calibration

Background:

• Cuff-less blood pressure (BP) measurement faces significant initial calibration challenges.
• Traditional one point-to-point (oPTP) calibration is sensitive to initial values and subject-specific physiological fluctuations.
• The initial sensitivity of calibration methods for cuff-less BP monitoring remains under-investigated.

Purpose of the Study:

• To introduce and evaluate novel calibration methods for cuff-less BP monitoring.
• To address the limitations of conventional oPTP calibration, specifically its sensitivity to initial values.
• To enhance the accuracy and reliability of BP estimation in cuff-less technologies.

Main Methods:

• Proposed a mean point-to-point (mPTP) calibration method by averaging calm state samples.
• Developed a factor point-to-point (fPTP) calibration method incorporating a penalty factor for optimization.
• Validated oPTP, mPTP, and fPTP methods using over 100,000 heartbeat samples from 21 healthy subjects in PTT-based BP monitoring.

Main Results:

• Both mPTP and fPTP methods demonstrated significant performance improvements in BP estimation compared to oPTP.
• The fPTP method showed particular efficacy in estimating cuff-less diastolic blood pressure (DBP).
• mPTP and fPTP methods reduce sensitivity to initial calibration values, enhancing individualized calibration.

Conclusions:

• The proposed mPTP and fPTP calibration methods offer superior performance for cuff-less BP estimation.
• These novel methods effectively mitigate the initial calibration sensitivity inherent in traditional approaches.
• The fPTP method shows strong potential for widespread application, especially for accurate cuff-less DBP monitoring.