Related Experiment Video
Updated: Dec 24, 2025

Extinction Training During the Reconsolidation Window Prevents Recovery of Fear
Published on: August 24, 2012
Forget the stress: retrograde amnesia for the stress-induced impairment of extinction retrieval
James F Briggs1, Kaitlyn M McMullen1
1Department of Psychology, Susquehanna University, Selinsgrove, Pennsylvania 17870, USA.
Abstract:
We investigated whether cycloheximide (CHX) would induce amnesia for the stress-induced impairment of extinction retrieval. First, a single restraint stress session was demonstrated to impair extinction retrieval, but not fear conditioning. A second experiment showed that when CHX was administered immediately after restraint, rats exhibited significant extinction retrieval at test (i.e., retrograde amnesia for the stress). In a third experiment, the stress session impaired various amounts of extinction durations, suggesting that the stress inhibited extinction retrieval rather than enhancing the original fear learning. These results suggest memories for acute stress are susceptible to disruption, which could have clinical implications.
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