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Related Experiment Video

Updated: Dec 24, 2025

Operant Procedures for Assessing Behavioral Flexibility in Rats

Operant Procedures for Assessing Behavioral Flexibility in Rats

Published on: February 15, 2015

Systems consolidation impairs behavioral flexibility.

Sankirthana Sathiyakumar^1,2, Sofia Skromne Carrasco¹, Lydia Saad¹

¹Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario M1C 1A4, Canada.

Learning & Memory (Cold Spring Harbor, N.Y.)

|April 17, 2020

Summary

This summary is machine-generated.

Systems consolidation, a memory process, impairs behavioral flexibility over time. Mice with longer memory consolidation periods struggled more with adapting to changes in rewards and action sequences.

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The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice

The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice

Published on: February 4, 2015

Area of Science:

Neuroscience
Cognitive Science
Animal Behavior

Background:

Behavioral flexibility is crucial for adapting to environmental changes.
Systems consolidation, a process of memory stabilization, may negatively impact this flexibility.
The precise mechanisms by which systems consolidation affects flexibility remain unclear.

Purpose of the Study:

To investigate how systems consolidation influences behavioral flexibility.
To examine the effects of consolidation on adapting to changes in reward value.
To assess the impact of consolidation on adapting to altered action sequences.

Main Methods:

Mice were trained on a Y-maze task requiring sequential nose pokes for rewards.
Following training, mice experienced either a 1-day or 28-day delay before encountering task modifications.
Task modifications included devaluation of a specific arm or reinforcement of a particular poke sequence.
Immediate early gene imaging was used to assess brain region reliance.

Main Results:

Mice showed greater adaptability to changes after a 1-day delay compared to a 28-day delay.
Adaptation to changes in the optimal action sequence was particularly challenging for mice with a 28-day delay.
Brain imaging indicated reduced hippocampal reliance and increased medial prefrontal cortex reliance in mice with longer delays.

Conclusions:

Systems consolidation progressively reduces behavioral flexibility.
This reduction in flexibility is more pronounced when adapting to changes in learned action sequences.
Long-term memory consolidation may shift neural reliance from the hippocampus to the medial prefrontal cortex, impacting adaptive behavior.