Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

1.0K
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
1.0K
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

332
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
332
Drug Dependence01:17

Drug Dependence

1.5K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.5K
CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

898
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
898
Stimulants01:29

Stimulants

754
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
754
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

652
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
652

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Opioids substitution therapy: A respect for the dignity of the human person].

L'Encephale·2021
Same author

Balneotherapy Together with a Psychoeducation Program for Benzodiazepine Withdrawal: A Feasibility Study.

Evidence-based complementary and alternative medicine : eCAM·2016
Same author

Deficit of cognitive inhibition in depressed elderly: a neurocognitive marker of suicidal risk.

Journal of affective disorders·2012
Same author

Correlations of cerebello-thalamo-prefrontal structure and neurological soft signs in patients with first-episode psychosis.

Acta psychiatrica Scandinavica·2011
Same author

Association of Disrupted in Schizophrenia 1 (DISC1) missense variants with ultra-resistant schizophrenia.

The pharmacogenomics journal·2010
Same author

[Assessment of metabolic impairments inducted by atypical antipsychotics among schizophrenic patients].

L'Encephale·2005
Same journal

[Advances and perspectives in vascularized composite allotransplantation preservation].

Bulletin de l'Academie nationale de medecine·2025
Same journal

[COVID-19: Neurological manifestations and complications during the acute phase of the disease].

Bulletin de l'Academie nationale de medecine·2024
Same journal

[Role of psychological factors in post-COVID-19 condition].

Bulletin de l'Academie nationale de medecine·2023
Same journal

[Neurological forms of long COVID in adults: Critical approach].

Bulletin de l'Academie nationale de medecine·2023
Same journal

[Post-COVID-19 syndrome].

Bulletin de l'Academie nationale de medecine·2023
Same journal

The next psychoactive drugs: From imipramine to ketamine.

Bulletin de l'Academie nationale de medecine·2023
See all related articles

Related Experiment Video

Updated: Dec 24, 2025

A Conflict Model of Reward-seeking Behavior in Male Rats
06:11

A Conflict Model of Reward-seeking Behavior in Male Rats

Published on: February 20, 2019

7.7K

[Addictive behaviors: Clinical facts].

C Lucet1, J P Olié2

  • 1Service addictologie, hôpital Sainte-Anne, Paris, France.

Bulletin De L'Academie Nationale De Medecine
|April 17, 2020
PubMed
Summary
This summary is machine-generated.

Substance use disorder is a distinct illness, not just a symptom of other mental health issues. Effective treatment requires addressing individual vulnerabilities and environmental factors with chemical, psychological, and social support.

Keywords:
Addiction medicine

More Related Videos

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience
08:14

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

12.0K
Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

1.3K

Related Experiment Videos

Last Updated: Dec 24, 2025

A Conflict Model of Reward-seeking Behavior in Male Rats
06:11

A Conflict Model of Reward-seeking Behavior in Male Rats

Published on: February 20, 2019

7.7K
Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience
08:14

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

12.0K
Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

1.3K

Area of Science:

  • Psychiatry
  • Neuroscience
  • Addiction Medicine

Context:

  • Increasing availability of novel synthetic substances online fuels emerging practices like chemsex and 'purple drank'.
  • Addictive behaviors stem from a complex interplay of individual vulnerabilities (biological, psychological) and environmental factors (substance accessibility, normalization).
  • Co-occurring mental health disorders increase vulnerability to substance use disorder, and addictive behaviors can signal underlying emotional or psychotic conditions.

Purpose:

  • To emphasize substance use disorder as an autonomous pathology.
  • To highlight the multifactorial etiology of addictive behaviors.
  • To advocate for a comprehensive therapeutic approach integrating various modalities.

Summary:

  • Substance use disorder (SUD) is recognized as an independent condition with unique determinants and progression, separate from psychiatric comorbidities.
  • Novel psychoactive substances and associated practices are emerging due to internet accessibility and chemical innovation.
  • Treatment necessitates a holistic strategy, addressing patient powerlessness and integrating chemical (including substitution), psychological, and social support to counteract desocialization.

Impact:

  • Enhances understanding of SUD as a primary disorder, guiding more accurate diagnosis and treatment planning.
  • Informs public health strategies regarding novel psychoactive substance control and harm reduction.
  • Promotes integrated care models for SUD, improving patient outcomes by addressing biological, psychological, and social dimensions.