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Klotho, the elusive kidney-derived anti-ageing factor

Maria Dolores Sanchez-Niño1, Beatriz Fernandez-Fernandez1, Alberto Ortiz1

  • 1IIS-Fundacion Jimenez Diaz, School of Medicine, Universidad Autonoma de Madrid; Fundacion Renal Iñigo Alvarez de Toledo-IRSIN and REDINREN, Madrid, Spain.

Clinical Kidney Journal
|April 17, 2020
PubMed

Insights

Early diagnosis of chronic kidney disease (CKD) is crucial. Improving Klotho assays may enable early CKD detection and monitoring, aiding in preventing disease progression and mortality.

Area of Science:

  • Nephrology
  • Biochemistry
  • Aging Research

Background:

  • Chronic kidney disease (CKD) is a rapidly growing global health concern, significantly increasing mortality.
  • Early diagnosis is key to preventing CKD progression and its impact on cardiovascular health.
  • Klotho, a kidney-produced protein, has anti-aging and phosphate-regulating functions, and its downregulation is an early indicator of kidney injury.

Discussion:

  • Current Klotho assays have suboptimal performance, hindering reliable monitoring.
  • Neyra et al. investigate methods to enhance the accuracy and dependability of Klotho assays.
  • Improved assays could facilitate early CKD detection and therapeutic monitoring.

Key Insights:

  • Klotho downregulation is an early sign of kidney damage.
  • Reliable Klotho assays are needed for early CKD diagnosis.
  • Enhancing assay performance is critical for clinical application.

Outlook:

  • Further research into assay optimization is essential.
  • Development of robust Klotho assays could revolutionize CKD management.
  • This work paves the way for improved patient outcomes in CKD.

Keywords:
Klothoblind spotchronic kidney diseaseproteomics

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