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The Sleep Apnea-Specific Hypoxic Burden Predicts Incident Heart Failure
Ali Azarbarzin1, Scott A Sands1, Luigi Taranto-Montemurro1
1Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Chest
|April 17, 2020
Summary
Sleep apnea-specific hypoxic burden (SASHB) predicts heart failure (HF) in men, unlike the apnea-hypopnea index (AHI). This finding highlights SASHB as a potential tool for identifying men at risk for heart disease.
Area of Science:
- Cardiology
- Sleep Medicine
- Public Health
Background:
- Heart failure (HF) is a major cause of illness and death.
- The link between sleep apnea and HF is known, but specific physiological stressors are unclear.
- Sleep apnea-specific hypoxic burden (SASHB) is a potential predictor of incident HF.
Purpose of the Study:
- To compare the predictive value of SASHB versus the apnea-hypopnea index (AHI) for incident HF.
- To investigate the association between SASHB and incident HF in two independent cohorts.
Main Methods:
- Utilized data from the Sleep Heart Health Study (SHHS) and the Outcomes of Sleep Disorders in Older Men (MrOS) cohorts.
- Calculated SASHB as the area under the desaturation curve related to sleep apnea.
- Employed Cox models to estimate hazard ratios (HRs) for SASHB and AHI, adjusting for confounders.
Main Results:
- SASHB significantly predicted incident HF in men across both cohorts (HRs ranging from 1.18 to 1.22 per 1SD increase).
- The apnea-hypopnea index (AHI) did not predict incident HF in men.
- Associations between SASHB and HF were observed in men regardless of AHI severity, but not in women.
Conclusions:
- In men, the hypoxic burden associated with sleep apnea predicts incident HF, independent of other risk factors.
- Quantifying SASHB may aid in identifying men at higher risk for heart disease.
- SASHB may represent a valuable target for future HF interventions.
Keywords:
apnea-hypopnea indexheart failurepolysomnographysleep apneasleep apnea-specific hypoxic burdenMore Related Videos
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