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Related Experiment Video

Updated: Dec 24, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Circulating metabolite profiles to predict response to cardiac resynchronization therapy.

Xue Gong¹, Zhonghan Sun², Zheyong Huang¹

¹Department of Cardiology, Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.

BMC Cardiovascular Disorders

|April 18, 2020

Summary

A novel blood metabolomic profile, including isoleucine, tryptophan, and linoleic acid, can predict patient response to cardiac resynchronization therapy (CRT) for heart failure. This discovery offers a potential biomarker for personalized CRT treatment strategies.

Keywords:

Cardiac resynchronization therapy Heart failure Metabolism

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Published on: March 24, 2023

Area of Science:

Cardiology
Metabolomics
Biomarker Discovery

Background:

Heart failure (HF) is linked to ventricular dyssynchrony and inefficiency, partially addressed by cardiac resynchronization therapy (CRT).
A significant non-response rate to CRT exists, highlighting the need for predictive biomarkers.
Currently, no specific biomarkers reliably predict CRT response in HF patients.

Purpose of the Study:

To investigate the utility of blood metabolomic profiles in predicting CRT response in patients with severe heart failure.
To identify specific metabolites or panels of metabolites associated with CRT responsiveness.

Main Methods:

A two-stage study involving 105 dilated cardiomyopathy patients with severe HF undergoing CRT.
Serum samples collected pre-CRT implantation analyzed using ultrahigh-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UHPLC-QTOF-MS).
Echocardiographic criteria used to define CRT response.

Main Results:

Seventeen metabolites differed significantly between CRT responders and non-responders.
Key affected metabolic pathways included linoleic acid metabolism, amino acid biosynthesis, and sphingolipid metabolism.
A panel of isoleucine, tryptophan, and linoleic acid demonstrated high accuracy (AUC 0.981 discovery, 0.929 validation) in distinguishing responders.

Conclusions:

Serum metabolomics effectively differentiates CRT responders from non-responders.
The identified metabolite panel (isoleucine, tryptophan, linoleic acid) shows significant prognostic value for CRT outcomes.