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Guidelines and definitions for research on epithelial-mesenchymal transition
Jing Yang1, Parker Antin2, Geert Berx3
1Departments of Pharmacology and Pediatrics, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA. jingyang@ucsd.edu.
Nature Reviews. Molecular Cell Biology
|April 18, 2020
Summary
Epithelial-mesenchymal transition (EMT) is a cellular process crucial in development and disease. This consensus statement provides unified terminology and guidelines for EMT research to improve clarity and collaboration.
Area of Science:
- Cell Biology
- Developmental Biology
- Cancer Biology
Background:
- Epithelial-mesenchymal transition (EMT) involves cellular changes affecting migration and invasion.
- EMT is implicated in various physiological and pathological conditions.
- Rapidly expanding EMT research necessitates standardized terminology.
Framework:
- This consensus statement, developed by TEMTIA, offers clear definitions and guidelines for EMT research.
- It aims to standardize nomenclature for epithelial-mesenchymal transition (EMT).
- The guidelines are based on a 2-year discussion among EMT researchers.
Implementation:
- Provides definitions and guidelines for future EMT research publications.
- Aims to reduce misunderstanding and misinterpretation of EMT data.
- Encourages cross-disciplinary collaboration in EMT research.
Implications:
- Facilitates a unified approach to studying EMT.
- Enhances understanding of developmental processes.
- Supports efforts to combat cancer and other diseases through consistent EMT research.
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