Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Cancer Therapies02:49

Cancer Therapies

9.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.7K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.5K
Cancer Vaccines01:30

Cancer Vaccines

871
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
871
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
The Tumor Microenvironment02:17

The Tumor Microenvironment

7.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Cervical Microbiome in Hispanic Populations in Texas and Puerto Rico with and without Cervical Dysplasia.

Research square·2026
Same author

Assessing predictors of brachytherapy utilization among cervical cancer patients in Nigeria: evidence from a tertiary cancer centre.

BMC cancer·2026
Same author

A New Remote Classroom Approach to Contouring Training for Pelvic Malignancies in Low- to Middle-Income Asian Countries.

Cureus·2026
Same author

Preoperative radiotherapy for appendicular bone metastases: outcomes.

BMJ supportive & palliative care·2026
Same author

Tumor microenvironment changes after treatment with avelumab and immune-stimulating agent combinations in patients with advanced solid tumors.

Research square·2026
Same author

Executive Summary of the American Radium Society (ARS) Appropriate Use Criteria (AUC) for Management of Locally Advanced Endometrial Cancer.

Practical radiation oncology·2026

Related Experiment Video

Updated: Dec 23, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

12.0K

Immunotherapy and Radiation.

Lauren E Colbert1, Anuja Jhingran2

  • 1Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Advances in Experimental Medicine and Biology
|April 18, 2020
PubMed
Summary
This summary is machine-generated.

Radiation therapy is crucial for cancer treatment, potentially enhancing the immune response. Combining radiation with immunotherapy shows promise, especially in definitive and oligometastatic settings, for improved cancer treatment outcomes.

Keywords:
Abscopal responseImmunotherapyRadiationRadiotherapy

More Related Videos

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.9K
Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

10.5K

Related Experiment Videos

Last Updated: Dec 23, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

12.0K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.9K
Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

10.5K

Area of Science:

  • Oncology
  • Immunology
  • Radiation Oncology

Background:

  • Radiation therapy is a cornerstone of cancer treatment, used for both curative and palliative purposes.
  • Radiation therapy can modulate the tumor immune microenvironment, with both immune-stimulating and immune-suppressive effects.
  • Understanding the complex interplay between radiation and the immune system is key to optimizing cancer therapy.

Purpose of the Study:

  • To explore the mechanisms by which radiation therapy influences the cancer immune cycle.
  • To evaluate the potential of combining radiation therapy with immunotherapy to overcome radiation-induced immunosuppression.
  • To assess the clinical promise of combination approaches in various cancer settings.

Main Methods:

  • Review of existing literature on radiation oncology and cancer immunology.
  • Analysis of preclinical and clinical data on radiation/immunotherapy combinations.
  • Exploration of immune-modulatory mechanisms of radiation therapy.

Main Results:

  • Radiation therapy can activate anti-tumor immune responses through multiple pathways.
  • Concurrent immunosuppressive effects of radiation may limit its efficacy as a monotherapy.
  • Limited clinical data exists for radiation/immunotherapy in metastatic cancer for abscopal response.

Conclusions:

  • Combination of radiation therapy and immunotherapy is a promising strategy to enhance anti-tumor immunity.
  • Optimizing combination approaches requires a deeper understanding of the underlying biological mechanisms.
  • Radiation/immunotherapy combinations show significant potential in the definitive and oligometastatic settings.